msl-1 Antibody

1. In Drosophila melanogaster, transcriptional output from the single male X-chromosome is equalized to that of XX females by recruitment of the male-specific lethal (MSL) complex, which increases transcript levels of active genes 2-fold. PMID: 27995349
2. We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation. PMID: 23209435
3. The Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome. PMID: 23084835
4. Data suggest that the Y chromosome is likely to act through modulation of a process that is defective in roX1 roX2 mutants: X chromosome recognition or chromatin modification by the MSL complex. PMID: 19704014
5. the amino-terminal region of MSL1 binds to hundreds of sites on the X chromosome in normal males but only to approximately 30 high-affinity sites in the absence of endogenous MSL1 PMID: 16199870
6. majority of the MSL-1 targets are primarily expressed during early embryogenesis and many target genes possess DNA replication element factor (DREF)-binding sites in their promoters PMID: 16547175
7. results demonstrate the potent capability of roX genes to organize large chromatin domains in cis, on the X chromosome; found that NURF complex and MSL proteins have opposing effects on roX RNA transcription. PMID: 17507677

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KEGG: dme:Dmel_CG10385

STRING: 7227.FBpp0080674

UniGene: Dm.458