MSN4 Antibody

1. e transcription factors also play an important role in the exit of quiescence and regrowth. By studying Saccharomyces cerevisiae under a continuous, nutrient-limited condition, we found that Msn2 and Msn4 function as master regulators of glycolytic genes in the quiescent-like phase. PMID: 29455333
2. Thus Msn2/4 exhibit a dual role in activating carbohydrate metabolism genes and stress response genes. PMID: 28949295
3. Data suggest that promoters of most genes involved in biogenesis, function, and regulation of peroxisomes contain msn2- and msn4-binding sites; msn2 exhibits increased occupancy on promoters of beta-oxidation genes in glucose-depleted conditions; thus, msn2 and msn4 transcription factors activate expression of genes involved in fatty acid oxidation. PMID: 28924051
4. Target genes of Msn2 and Msn4 with fast activation kinetics can be fully induced by either factor, behaving as an 'OR' gate. In contrast, target genes with slow activation kinetics behave as an 'AND' gate, requiring distinct contributions from both factors, upon transient stimulation. PMID: 27690227
5. suppression of Msn2/Msn4 activity in the absence of stress is achieved by several independent control mechanisms, including Msn2/Msn4 phosphorylation and proteosome degradation PMID: 21757539
6. The anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of Saccharomyces cerevisiae in an Msn2-, Msn4-dependent manner. PMID: 20846146
7. Crz1 destabilizes Msn2/Msn4 in the nuclei of cells in response to Ca2+ signalling. PMID: 20121702
8. This study discovered the Msn2p and Msn4p (Msn2/4p) transcriptional activator proteins to be an additional control mechanism inducing the stress response during zinc deficiency. PMID: 19702872
9. role of Msn2 and Msn4 in mediating the transcriptional response of short term anaerobiosis PMID: 15870279
10. elevated pressure activates STRE dependent transcription through Msn2/4, which are also required for cell resistance and cell adaptation to high pressure. PMID: 17055490
11. The double deletion of MSN2 and MSN4 eliminates both chromatin remodeling and heat shock factor binding only at the HSP12 promoter, suggesting that Msn2/4 activators are primary determinants of chromatin disassembly at the HSP12 promoter. PMID: 18070923
12. NuA4 physically interacts with Msn4 but does not regulate Msn4 binding to the HSP12 promoter or heat shock induction of HSP12. PMID: 18212056
13. In this review, Msn2 and Msn4 regulation during heat stress is discussed. PMID: 19435282

Show More

Hide All

KEGG: sce:YKL062W

STRING: 4932.YKL062W