SelR Antibody

Code CSB-PA815531XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) SelR Polyclonal antibody
Uniprot No.
Target Names
SelR
Alternative Names
SelR antibody; MsrB antibody; MsrB1 antibody; CG6584 antibody; Methionine-R-sulfoxide reductase B1 antibody; EC 1.8.4.12 antibody; Selenoprotein R antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) SelR protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.
Gene References into Functions
  1. SelR opposes Mical redox activity and Semaphorin-Plexin repulsion to direct multiple actin-dependent cellular behaviours in vivo. PMID: 24212093
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
Protein Families
MsrB Met sulfoxide reductase family
Tissue Specificity
Present in the embryonic nervous system (brain and cord) in neuronal cell bodies, along axons. Also present in embryonic muscles in motor axons. Localizes to growing bristle tips where it is distributed in small puntae. Present at and at sites of actin lo
Database Links

KEGG: dme:Dmel_CG6584

STRING: 7227.FBpp0081772

UniGene: Dm.1144

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