mtm-3 Antibody

Code CSB-PA633804XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mtm-3 Polyclonal antibody
Uniprot No.
Target Names
mtm-3
Alternative Names
mtm-3 antibody; T24A11.1 antibody; Myotubularin-related protein 3 antibody; ceMTM3 antibody; EC 3.1.3.48 antibody; Myotubularin homologous protein 1 antibody; ceMTMH1 antibody; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase antibody; EC 3.1.3.95 antibody; Phosphatidylinositol-3-phosphate phosphatase antibody; EC 3.1.3.64 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mtm-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Preferentially dephosphorylates phosphatidylinositol 3-phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination.
Gene References into Functions
  1. MTM-3 is recruited to autophagosomes by PtdIns3P, and loss of MTM-3 causes increased autophagic association of ATG-18 in a PtdIns3P-dependent manner. PMID: 25124690
  2. A role of ceMTM3 is in regulating autophagy and maintaining muscle fibers. PMID: 23114011
  3. This study thus reveals an important role of the MTM phosphatases in maintaining muscle function. PMID: 18393358
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Tissue Specificity
Expressed in the body wall muscle and in eggs. Expressed in head neurons. Expressed in the intestine. Expressed in pharyngeal cells, vulval muscle cells and cells of the tail region.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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