SLM3 Antibody

Code CSB-PA604905XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SLM3 Polyclonal antibody
Uniprot No.
Target Names
SLM3
Alternative Names
SLM3 antibody; MTO2 antibody; MTU1 antibody; YDL033C antibody; D2761 antibody; Mitochondrial tRNA-specific 2-thiouridylase 1 antibody; EC 2.8.1.14 antibody; Mitochondrial translation optimization protein 2 antibody; Synthetic lethal with MSS4 3 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SLM3 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Gene References into Functions
  1. The identification and characterization of MTU1 (mitochondrial tRNA-specific 2-thiouridylase 1), a tRNA-modifying enzyme that is responsible for the 2-thiolation of the wobble position in mitochondrial tRNAs. [MTU1] PMID: 15509579
  2. These data strongly indicate that unmodified tRNA caused by the deletion of MTO2 caused the instability of mitochondrial tRNAs and mRNAs and impairment of aminoacylation of tRNAs. PMID: 17706197
Subcellular Location
Mitochondrion.
Protein Families
MnmA/TRMU family
Database Links

KEGG: sce:YDL033C

STRING: 4932.YDL033C

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