Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Mmp24 Polyclonal antibody

Uniprot No.

Q9R0S2

Target Names

Mmp24

Alternative Names

Mmp24 antibody; Mmp21 antibody; Mt5mmpMatrix metalloproteinase-24 antibody; MMP-24 antibody; EC 3.4.24.- antibody; Matrix metalloproteinase-21 antibody; MMP-21 antibody; Membrane-type matrix metalloproteinase 5 antibody; MT-MMP 5 antibody; MTMMP5 antibody; Membrane-type-5 matrix metalloproteinase antibody; MT5-MMP antibody; MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24] antibody

Raised in

Rabbit

Species Reactivity

Mus musculus

Immunogen

Recombinant Mus musculus Mmp24 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Target Background

Function

Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.

Gene References into Functions

MT5-MMP emerges as a new pro-amyloidogenic regulator of APP metabolism, whose deficiency alleviates amyloid pathology, neuroinflammation and cognitive decline. PMID: 26202697
APP carboxy-terminal fragment generation is mediated in part by membrane-bound matrix metalloproteinases such as MT5-MMP, referred to as eta-secretase activity PMID: 26322584
identify MT5-MMP as a membrane-type metalloproteinase responsible for the shedding of the N-cadherin ectodomain in this niche PMID: 24952463
MT5-MMP-deficient mice did not develop neuropathic pain with mechanical allodynia after sciatic nerve injury. PMID: 14741353
MT5-MMP retrieval to the plasma membrane is regulated by Mint-3 by binding to its carboxyl end motif EWV PMID: 14990567
These results suggest that ABP directs MT5-MMP proteolytic activity to growth cones and synaptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of cadherins or other ECM or cell adhesion molecules. PMID: 16495457
Findings demonstrate an essential role of MT5-MMP in the development of dermal neuro-immune synapses and suggest that this metalloproteinase may be a target for pain control. PMID: 19805319

Hide All

Subcellular Location

[Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix.

Protein Families

Peptidase M10A family

Tissue Specificity

Mainly expressed in neuronal cells of both central and peripheral nervous systems. Expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia. Expressed in adult neural stem cell and ependymocytes. Expressed at low level in testis.

Database Links

KEGG: mmu:17391

STRING: 10090.ENSMUSP00000029141

UniGene: Mm.389325

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA879497ZA01MO
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Mmp24 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background