NAM7 Antibody

1. The propose that the Sse1/Hsp70 complex maintains the solubility of FLAG-Pgk1-300, thereby stimulating its Upf-dependent degradation by the proteasomes. PMID: 28483531
2. The study provides evidence that two tyrosines within a phospho-motif of Upf1 act redundantly to promote ATP hydrolysis, Nonsense-Mediated mRNA Decay efficiency and translation termination fidelity. PMID: 24198248
3. The cysteine- and histidine-rich (CH) domain and the RNA helicase domain of yeast Upf1 can engage in two new types of molecular interactions: an intramolecular interaction between these two domains and self-association of each of these domains. PMID: 24100012
4. The upf1Delta mutant contained elevated copper levels in the vacuole relative to wild-type yeast cells, after both strains were exposed to elevated copper levels. Copper tolerance by the upf1Delta mutant is dependent on the presence of CTR2. PMID: 23450501
5. Results indicate that Upf1 plays a key role in a mechanism coupling termination and ribosome release at a premature termination codon to subsequent ribosome reutilization for another round of translation initiation. PMID: 20675403
6. Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome PMID: 19798102
7. interaction between Upf1p and the nuclear pore proteins, Nup100p and Nup116p, is significant because it suggests a mechanism to ensure that Upf1p associates with newly synthesized mRNA as it is transported from the nucleus to the cytoplasm PMID: 15716093
8. Upf1p associates with direct substrates of the NMD pathway PMID: 18087042

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KEGG: sce:YMR080C

STRING: 4932.YMR080C