nanA Antibody

Datasheet

Code	CSB-PA015994XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) nanA Polyclonal antibody

Uniprot No.

P0A6L4

Target Names

nanA

Alternative Names

nanA antibody; npl antibody; b3225 antibody; JW3194 antibody; N-acetylneuraminate lyase antibody; NAL antibody; Neu5Ac lyase antibody; EC 4.1.3.3 antibody; N-acetylneuraminate pyruvate-lyase antibody; N-acetylneuraminic acid aldolase antibody; NALase antibody; Sialate lyase antibody; Sialic acid aldolase antibody; Sialic acid lyase antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

A synthesized peptide derived from Escherichia coli (strain K12) nanA protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, Dot blot (guaranteed specific to the immunizing peptide)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

①. 100ug * KLH-conjugated peptide paired with 100ug * BSA-conjugated peptide (positive control);
②. 1ml*pre-immune serum (used as negative control) for free;
③. Rabbit polyclonal antibodies purified by Antigen Affinity;

Quality Guarantee

1. CUSABIO guarantees the antibody purity > 95% confirmed by SDS-PAGE.
2. CUSABIO guarantees the antibody titer > 1: 64,000 confirmed by ELISA.
3. CUSABIO guarantees to offer Peptide-specific Dot blot.
4. CUSABIO guarantees 100% risk-free: No qualified antibody, no charge.

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Experiments show the true substrate is aceneuramate (linearized Neu5Ac), which forms spontaneously at alkaline pH. Linear aceneuramate can be provided by NanQ.

Gene References into Functions

analysis of modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251 PMID: 21270125
A comparison of mutant and wild-type nanA structures, in combination with the specificity profiles of the variants, reveals subtle differences that explain the details of the substrate specificity changes. PMID: 20826162
Results describe the structure of a mutant variant of Escherichia coli N-acetyl-d-neuraminic acid lyase (NAL), E192N, in complex with pyruvate in a new crystal form. PMID: 19923724
the dimer-dimer interface of NAL is intolerant to mutation and essential for functional expression. PMID: 19646958

Subcellular Location

Cytoplasm.

Protein Families

DapA family, NanA subfamily

Database Links

KEGG: ecj:JW3194

STRING: 316385.ECDH10B_3402

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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nanA Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background