CDase Antibody

Code CSB-PA892700XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) CDase Polyclonal antibody
Uniprot No.
Target Names
CDase
Alternative Names
CDase antibody; slab antibody; CG1471 antibody; Neutral ceramidase antibody; N-CDase antibody; NCDase antibody; EC 3.5.1.23 antibody; Neutral N-acylsphingosine amidohydrolase antibody; Neutral acylsphingosine deacylase antibody; Slug-a-bed protein antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) CDase protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition.
Gene References into Functions
  1. findings show the neutral ceramidase gene CDase encodes the protein that is responsible for all measurable ceramidase activity in Drosophila; studies show strong genetic interaction of Bwa with CDase and the ceramide kinase gene PMID: 21148295
  2. Data report the molecular cloning and characterization of the Drosophila neutral ceramidase. PMID: 12153720
  3. SLAB ceramidase function controls presynaptic terminal sphingolipid composition to regulate vesicle fusion and trafficking, and thus the strength and reliability of synaptic transmission PMID: 15356190
Subcellular Location
Secreted.
Protein Families
Neutral ceramidase family
Tissue Specificity
Widely expressed in different tissues but enriched in neurons at all stages of development.
Database Links

KEGG: dme:Dmel_CG1471

STRING: 7227.FBpp0303775

UniGene: Dm.16294

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