gei-8 Antibody

Code CSB-PA327313XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gei-8 Polyclonal antibody
Uniprot No.
Target Names
gei-8
Alternative Names
gei-8 antibody; pqn-12 antibody; C14B9.6 antibody; Nuclear receptor corepressor 1 antibody; N-CoR antibody; N-CoR1 antibody; Gex-3-interacting protein 8 antibody; Prion-like-(Q/N-rich) domain-bearing protein 12 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gei-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
Gene References into Functions
  1. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. PMID: 23484030
  2. Knockdown of gei-8, the sole C. elegans NCoR homolog, robustly increased muscle mitochondria and respiration, suggesting evolutionary conservation of NCoR1 function. PMID: 22078881
Subcellular Location
Nucleus.
Protein Families
N-CoR nuclear receptor corepressors family
Tissue Specificity
In larvae, expressed in pharyngeal neurons, ventral and dorsal nerve cords, tail neurons, egg-laying neurons and egg-laying muscles. Detected in the neurons of the pharyngeal nerve ring, head neurons, tail neurons and egg-laying muscles in adults. Detecte
Database Links

KEGG: cel:CELE_C14B9.6

STRING: 6239.C14B9.6b

UniGene: Cel.22961

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