nef Antibody

Code CSB-PA322407XA01HLX
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Product Details

Full Product Name
Rabbit anti-Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2) nef Polyclonal antibody
Uniprot No.
Target Names
nef
Alternative Names
nef antibody; Protein Nef antibody; 3'ORF antibody; Negative factor antibody; F-protein antibody
Raised in
Rabbit
Species Reactivity
Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
Immunogen
Recombinant Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2) nef protein
Immunogen Species
Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells. One of the earliest and most abundantly expressed viral proteins.; In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules.; Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
Subcellular Location
Host cell membrane; Lipid-anchor; Cytoplasmic side.
Protein Families
Lentivirus primate group Nef protein family
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