Clbn Antibody

Code CSB-PA896069XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Clbn Polyclonal antibody
Uniprot No.
Target Names
Clbn
Alternative Names
Clbn antibody; CG11847Nuclear export mediator factor NEMF homolog antibody; Protein Caliban antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Clbn protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Binds to Ala- and Thr-tRNAs and, to a lesser extent, Ser-tRNA. On mitochondrial surface, plays a role in mitochondrial-stress induced translational termination impairment and protein carboxyl terminal extension (MISTERMINATE). Important for the stable association of l(3)76BDr/LTN1 to the complex. Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. Plays a role in the regulation of G1-to-S cell cycle transition. Regulates S phase checkpoint by antagonizing E2F1 activity. Together with hid and tefu/ATM, plays a role in DNA damage-induced apoptosis through both p53-dependent and -independent activity. Plays an essential role in the regulation of mitochondrial structure and redox state in enterocytes which is essential for the control of intestinal stem cells proliferation and intestinal homeostasis.
Gene References into Functions
  1. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways. PMID: 22964637
  2. Expression of fly caliban in human lung cancer cells restores non-functional nuclear export of lung cancer cells, impairs a cell's ability to form colonies on soft agar and reduces cell invasiveness PMID: 16103875
Subcellular Location
Nucleus. Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
NEMF family
Tissue Specificity
Expressed in enterocytes (at protein level).
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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