Nep2 Antibody

Code CSB-PA259452XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Nep2 Polyclonal antibody
Uniprot No.
Target Names
Nep2
Alternative Names
Nep2 antibody; CG9761 antibody; Neprilysin-2 antibody; EC 3.4.24.11) [Cleaved into: Neprilysin-2 antibody; soluble form] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Nep2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues. Functions in female fertility, embryogenesis and memory formation. Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates. Also required for normal patterns of hatching due to its important role in early embryonic development. Required in the dorsal paired medial neurons for the proper formation of middle-term memory. Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation.
Gene References into Functions
  1. The NEP2 involved in middle-term memory (MTM) and long-term memory (LTM) and that their expression is required in the mushroom bodies and also in a single pair of closely connected neurons. PMID: 27629706
Subcellular Location
Cell membrane; Single-pass type II membrane protein. Secreted.
Protein Families
Peptidase M13 family
Tissue Specificity
Detected in the stellate cells in the main segment and the bar-shaped cells in the initial segment of male and female Malpighian tubules (at protein level). Expressed in the spermatheca (at protein level). Expressed in the somatic cyst cells of the testes
Database Links

KEGG: dme:Dmel_CG9761

STRING: 7227.FBpp0293663

UniGene: Dm.2492

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