neur Antibody

Code CSB-PA329914XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) neur Polyclonal antibody
Uniprot No.
Target Names
neur
Alternative Names
neur antibody; neu antibody; CG11988 antibody; Protein neuralized antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) neur protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
Gene References into Functions
  1. the NHR2 domain is required for Neur function, and a point mutation in the NHR2 domain (Gly430) abolishes Neur ubiquitination activity and affects ligand internalization PMID: 23045391
  2. D-mib and Neur are two structurally distinct proteins that have similar molecular activities but distinct developmental functions in Drosophila. PMID: 15760269
  3. E3 ubiquitin ligase neuralized is required for both Delta endocytosis and the internalization of Sanpodo PMID: 15901829
  4. DSL internalization and signaling are promoted in Drosophila by the ubiquitin ligases Mind bomb (Mib) and Neuralized (Neur) PMID: 15930117
  5. Tom antagonizes the activity of Neuralized and thus establishes a sharp mesoderm-mesoectoderm boundary of Notch signaling. PMID: 16459304
  6. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import. PMID: 18076903
  7. The diverse phenotypic effects arising from nearby P-element insertions in neur provide a new appreciation of the concept of allelic effects on phenotype. PMID: 18562639
  8. the highly conserved ubiquitin ligase Neuralized (Neur) is expressed in the adult Drosophila mushroom body (MB) alpha/beta lobe peripheral neurons and is a limiting factor for the formation of long-term memory PMID: 18794519

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Subcellular Location
Nucleus.
Database Links

KEGG: dme:Dmel_CG11988

STRING: 7227.FBpp0081481

UniGene: Dm.1114

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