Rel Antibody

1. Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression. PMID: 25931442
2. The Toll/NF-kappaB signaling pathway is required for epidermal wound repair in Drosophila. PMID: 25427801
3. Epistatic analysis indicates that DMAP1 acts in parallel or downstream of Relish. PMID: 24947515
4. the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response PMID: 24733183
5. Relish mutations inhibited upregulation of innate immune response genes and neurodegeneration in ATM mutants. PMID: 23502677
6. induction of antimicrobial peptide expression is via activation of the NF-kappaB transcription factor Relish in the immune deficiency (Imd) pathway PMID: 22470576
7. NF-kappaB transcription factor Relish mediates the alternative pathway of cell death in Drosophila PMID: 22328149
8. Data show that inhibition of NF-kappaB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. PMID: 21483034
9. Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling. PMID: 21297578
10. immune response increases sleep in flies in a manner that is gated by the circadian clock and that requires the NFkappaB Relish; supports a role of sleep in a recovery process and demonstrate a conserved feature of the Drosophila model of sleep. PMID: 20144235
11. activation is controlled by PGRP-LC PMID: 11872802
12. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in larvae. PMID: 12359879
13. a caspase target site, located in the linker region between the Rel and the IkappaB-like domain, is the site of signal-dependent cleavage PMID: 12732719
14. Rel synergy with GATA plays a pervasive role in the immune response. PMID: 14731391
15. Rel limits duration of JNK activation in response to Gram-neg infections. Rel activation is linked to TAK1 degradation, terminating JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID: 15037551
16. Molecular modeling was used to compare the tertiary structure of Relish with two other Drosophila proteins. PMID: 17785540
17. the C-terminal IkappaB-like domain executes a scaffolding and recruiting function for full activation of Relish. PMID: 19135474
18. show that the IKK complex controls Relish by direct phosphorylation on serines 528 and 529. Surprisingly, these phosphorylation sites are not required for Relish cleavage, nuclear translocation, or DNA binding PMID: 19497884

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KEGG: dme:Dmel_CG11992

STRING: 7227.FBpp0088375

UniGene: Dm.4154