png-1 Antibody

Datasheet

Code	CSB-PA883315XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans png-1 Polyclonal antibody

Uniprot No.

Q9TW67

Target Names

png-1

Alternative Names

png-1 antibody; F56G4.5 antibody; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase antibody; EC 3.5.1.52 antibody; Peptide:N-glycanase antibody; PNGase antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans png-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Also displays oxidoreductase (thioredoxin) activity. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction.

Gene References into Functions

Caenorhabditis elegans PNG-1 exhibits dual enzyme functions, not only as PNGase but also as an oxidoreductase (thioredoxin). PMID: 17509531
Authors show a developmental role for a PNGase and Rad-23 in the regulation of neuronal branching during organ innervation. PMID: 20130186

Subcellular Location

Cytoplasm. Endoplasmic reticulum. Note=ER localization inferred from partial colocalization with an ER marker, membrane protein PIG-X.

Protein Families

Transglutaminase-like superfamily, PNGase family

Database Links

KEGG: cel:CELE_F56G4.5

STRING: 6239.F56G4.5.1

UniGene: Cel.18605

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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png-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background