NHP6A Antibody

1. The yeast HMG box protein NHP6A shows DNA-segment-facilitated dissociation effects similar to those of Fis. PMID: 26220077
2. adapt two high-resolution in vivo protein-mapping techniques to demonstrate direct binding of the heterologous Nhp6A protein at a LacI repression loop in living E. coli cells PMID: 26039992
3. Observations support a model in which the HMGB protein Nhp6A soften DNA through random dynamic binding and dissociation, accompanied by DNA kinking and straightening, respectively. PMID: 23221634
4. While all of the HMGB proteins bend DNA to preferred angles, Nhp6A promoted the formation of higher-order oligomer structures. PMID: 22197373
5. Chromatin-dependent binding of the S. cerevisiae HMGB protein Nhp6A affects nucleosome dynamics and transcription PMID: 20844014
6. Analysis of mechanical response generated by binding of DNA-bending protein NHP6A to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing NHP6A concentration. PMID: 15504049
7. NHP6A is required for transcription of a subset of tRNA genes and heterochromatin barrier function. PMID: 17178828
8. Nhp6Ap has a role in the evolutionarily conserved calmodulin-dependent nuclear import pathway PMID: 17878171
9. An isolated HMG box A domain from human HMGB2 does not enhance DNA flexibility. Substitution of a small number of cationic residues from the N-terminal leader of a functional yeast box B protein, Nhp6Ap, confers the ability to enhance DNA flexibility. PMID: 19236006

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KEGG: sce:YPR052C

STRING: 4932.YPR052C