nhr-49 Antibody

1. Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function PMID: 27783623
2. AAK-2 regulates oxidative metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 transcriptional regulators. PMID: 26824904
3. NHR-49 may facilitate the adaptation to loss of reproductive potential through synchronized enhancement of fatty-acid oxidation and desaturation,and orchestrating a lipid profile conducive for somatic maintenance and longevity. PMID: 25474470
4. Data (including data from studies in mutant and transgenic strains) suggest that stress response to fasting (lysosomal lipid accumulation) is co-ordinately regulated by EGL-4/PKG (protein kinase G) and nuclear hormone receptor NHR-49. PMID: 24854345
5. Fibrates promote C. elegans longevity in an NHR-49-dependent manner possibly by promoting mitohormesis and suggesting that these compounds may promote lifespan also in mammals. PMID: 23603800
6. Caenorhabditis elegans NHR gene nhr-49 yielded worms with elevated fat content and shortened life span. PMID: 15719061
7. Knockdown of mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in vivo, and fasting-independent expression of other NHR-49 target genes. PMID: 16651656
8. nhr-49 has a role in regulating lipid synthesis, beta-oxidation of fatty acids, glycolysis and gluconeogenesis in a similar manner to the role of PPAR-alpha in the mouse liver. PMID: 18435929
9. findings show the starvation-sensing nuclear receptor NHR-49 is required for adult reproductive diapause entry and recovery PMID: 19713489

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KEGG: cel:CELE_K10C3.6

STRING: 6239.K10C3.6c.2

UniGene: Cel.17842