nhr-8 Antibody

Code CSB-PA893629XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans nhr-8 Polyclonal antibody
Uniprot No.
Target Names
nhr-8
Alternative Names
nhr-8 antibody; F33D4.1Nuclear hormone receptor family member nhr-8 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans nhr-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Orphan nuclear receptor.
Gene References into Functions
  1. Pdda is abolished by synthetic ascarosides and steroidal ligands of the nuclear hormone receptor DAF-12. We show that neither ascarosides nor any known steroid hormones are required for Pdda and that another chemical signal mediates this phenotype, in part via the nuclear hormone receptor NHR-8. PMID: 28394895
  2. Dafachronic acid signaling through NHR-8 is essential for diet restriction-mediated longevity. PMID: 25209682
  3. Knockdown of the NHR-8 nuclear receptor enhanced sensitivity to the lipid-reducing activity of alkaloids in Caenorhabditis elegans. PMID: 25052035
  4. C. elegans NHR-8 NR, a homolog of vertebrate liver X and vitamin D receptors, regulates nematode cholesterol balance, fatty acid desaturation, apolipoprotein production, and bile acid metabolism. PMID: 23931753
Subcellular Location
Nucleus.
Protein Families
Nuclear hormone receptor family
Database Links

KEGG: cel:CELE_F33D4.1

STRING: 6239.F33D4.1a

UniGene: Cel.18186

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