lit-1 Antibody

Code CSB-PA866194XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans lit-1 Polyclonal antibody
Uniprot No.
Target Names
lit-1
Alternative Names
lit-1 antibody; nlk antibody; W06F12.1 antibody; Serine/threonine kinase NLK antibody; EC 2.7.11.24 antibody; Loss of intestine protein 1 antibody; Nemo-like kinase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans lit-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis.
Gene References into Functions
  1. Results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size. PMID: 21857800
  2. Overexpressing lit-1 causes heterochronic defects opposite to those in lit-1(lf) mutants. LIT-1 exhibits a periodic expression pattern in seam cells within each larval stage PMID: 20624379
Subcellular Location
Cytoplasm, cell cortex. Nucleus.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Tissue Specificity
Expressed in the pharynx and seam and vulval cells.
Database Links

KEGG: cel:CELE_W06F12.1

STRING: 6239.W06F12.1a

UniGene: Cel.6733

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