nmad-1 Antibody

Code CSB-PA905940XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans nmad-1 Polyclonal antibody
Uniprot No.
Target Names
nmad-1
Alternative Names
nmad-1 antibody; F09F7.7 antibody; DNA N6-methyl adenine demethylase antibody; EC 1.14.11.51 antibody; N6-methyl adenine demethylase 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans nmad-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Plays an essential role in DNA replication and repair in the germline during meiosis. Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication.
Gene References into Functions
  1. These findings suggested that F09F7.7 may act as a 6mA demethylase in vivo, which is further supported by the biochemical experiments thus authors renamed F09F7.7 N6-methyl adenine demethylase 1 (nmad-1) to reflect this newly identified function. PMID: 25936839
Subcellular Location
Nucleus.
Protein Families
AlkB family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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