norM Antibody

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Code	CSB-PA528111XA01FVD
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Target Background

Product Details

Full Product Name

Rabbit anti-Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) norM Polyclonal antibody

Uniprot No.

O82855

Target Names

norM

Alternative Names

norM antibody; VP1479 antibody; Multidrug resistance protein NorM antibody; Multidrug-efflux transporter antibody; Na(+)/drug antiporter antibody

Raised in

Rabbit

Species Reactivity

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

Immunogen

Recombinant Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) norM protein

Immunogen Species

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to several drugs, such as norfloxacin, ciprofloxacin, ethidium, kanamycin and streptomycin.

Gene References into Functions

In this study, we investigated the role(s) of acidic amino acid residues Asp32, Glu251, and Asp367 in the transmembrane region of NorM by site-directed mutagenesis. PMID: 15716425
Inactivation of norM rendered V. cholerae hypersensitive towards fluoroquinolones such as norfloxacin/ciprofloxacin. Moreover the topology of NorM was determined and amino acid residures involved in norfloxacin resistance was identified. PMID: 16954325
A gene (norM) for a putative multidrug efflux protein shows different substrate specificities in V. parahaemolyticus and E. coli PMID: 9661020
In this study, we conclude that NorM is an Na(+)-driven Na(+)/drug antiporter, which is the first example in the biological world. PMID: 11073914

Subcellular Location

Cell inner membrane; Multi-pass membrane protein.

Protein Families

Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Database Links

KEGG: vpa:VP1479

STRING: 223926.VP1479

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norM Antibody

Product Details

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Customer Reviews and Q&A

Target Background