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Code	CSB-PA894281XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) not Polyclonal antibody

Uniprot No.

Q9VVR1

Target Names

not

Alternative Names

not antibody; CG4166 antibody; Ubiquitin carboxyl-terminal hydrolase nonstop antibody; EC 3.4.19.12 antibody; Deubiquitinating enzyme nonstop antibody; Ubiquitin thioesterase nonstop antibody; Ubiquitin-specific-processing protease nonstop antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) not protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.

Gene References into Functions

Data establish that Nonstop actually functions as an ubiquitin protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8 PMID: 18188155
3 additional subunits of TFTC/STAGA (dSgf11, non-stop, & en(y)2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila. PMID: 18206972

Subcellular Location

Nucleus.

Protein Families

Peptidase C19 family, UBP8 subfamily

Tissue Specificity

Expressed in the optic lobe and central brain. Highly expressed in the lamina precursor cells but not in differentiated lamina neurons. Also expressed in marginal, epithelial and medulla glial cells adjacent to the lamina plexus.

Database Links

KEGG: dme:Dmel_CG4166

STRING: 7227.FBpp0288698

UniGene: Dm.2731

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