CDC39 Antibody

Code CSB-PA328556XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC39 Polyclonal antibody
Uniprot No.
Target Names
CDC39
Alternative Names
CDC39 antibody; NOT1 antibody; ROS1 antibody; YCR093W antibody; YCR1151 antibody; YCR93W antibody; General negative regulator of transcription subunit 1 antibody; Cell division cycle protein 39 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC39 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Gene References into Functions
  1. Studies indicate that the Ccr4 (carbon catabolite repressed 4)-Not (negative on TATA-less) complex has been connected to every step of the mRNA lifecycle. PMID: 26614669
  2. The interplay between Ccr4-Not and Rpb4/7 described here suggests a mechanism for how the cell coordinates mRNA synthesis and decay PMID: 25315781
  3. Not2 and Not5 have extended regions that wrap around Not1 and around their globular domains, the Not boxes. PMID: 24121231
  4. A MIF4G domain positioned centrally within the Not1 protein recognizes Caf1, which in turn binds the LRR domain of Ccr4 and tethers the Ccr4 nuclease domain. PMID: 22959269
  5. Results describe the structure of the purified CCR4-NOT complex as determined by electron microscopy. PMID: 21669201
  6. the Ccr4-Not complex independently controls TFIID promoter distribution and Msn2-dependent trans-activation through a process involving a Glc7/Bud14 phosphatase PMID: 15601868

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
CNOT1 family
Database Links

KEGG: sce:YCR093W

STRING: 4932.YCR093W

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