Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Nrx-IV Polyclonal antibody

Uniprot No.

Q94887

Target Names

Nrx-IV

Alternative Names

Nrx-IV antibody; Nrx antibody; CG6827 antibody; Neurexin-4 antibody; Neurexin IV antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Nrx-IV protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.

Gene References into Functions

DNrx promotes ephrin clustering and reveals that ephrin/Eph signaling from adjacent L4 neurons restricts axonal branches of L4 neurons in columns. PMID: 28366281
Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin.[Tcf4] PMID: 27050508
Neurexin mediates retinoid transport and subsequent rhodopsin maturation in visual function; the Drosophila homolog of alpha-neurexin is critical for fly visual function. PMID: 23352167
The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. PMID: 22461565
The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin. PMID: 22022470
The possibility that neurexin is present postsynaptically raises new hypotheses regarding neurexin function in synapses, and our results provide new insights into the role of neurexin in synapse development PMID: 20559439
Nrx IV is essential for proper Robo localization and repulsive axon guidance, and is a novel interacting partner of the Slit/Robo signaling pathway. PMID: 20410118
Loss of Nrx IV leads to defects in ommatidial morphology and integrity. PMID: 18407259

Hide All

Subcellular Location

Membrane; Single-pass type I membrane protein. Cell junction, septate junction.

Protein Families

Neurexin family

Tissue Specificity

Found in septate junctions of epithelial and glial cells.

Database Links

KEGG: dme:Dmel_CG6827

STRING: 7227.FBpp0075730

UniGene: Dm.1843

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA842455XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Nrx-IV Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background