NS1 Antibody

Code CSB-PA321612ZA01PQB
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Product Details

Full Product Name
Rabbit anti-Porcine parvovirus (strain NADL-2) (PPV) NS1 Polyclonal antibody
Uniprot No.
Target Names
NS1
Alternative Names
NS1 antibody; Initiator protein NS1 antibody; NS1 antibody; EC 3.1.21.- antibody; EC 3.6.4.12 antibody; NCVP1 antibody; Non-capsid protein NS-1 antibody; Non-structural protein 1 antibody; Non-structural protein NS1 antibody
Raised in
Rabbit
Species Reactivity
Porcine parvovirus
Immunogen
Recombinant Porcine parvovirus NS1 protein
Immunogen Species
Porcine parvovirus (strain NADL-2) (PPV)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication. Also plays a role in viral packaging and transactivation of several promoters. Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR). Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1. Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis. The helicase activity unwinds DNA in a 3'-5' direction on the longer strand. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Promotes apoptosis in host cell.
Subcellular Location
Host nucleus.
Protein Families
Parvoviruses non-capsid protein family
Database Links

KEGG: vg:1489594

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