NUDT3 Antibody

Code CSB-PA530966XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NUDT3 Polyclonal antibody
Uniprot No.
Target Names
NUDT3
Alternative Names
5''''-P1 antibody; Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1 antibody; Diadenosine 5'' antibody; Diphosphoinositol polyphosphate phosphohydrolase 1 antibody; Diphosphoinositol polyphosphate phosphohydrolase antibody; DIPP 1 antibody; DIPP antibody; DIPP-1 antibody; DIPP1 antibody; Nucleoside diphosphate linked moiety X motif 3 antibody; Nucleoside diphosphate-linked moiety X motif 3 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 3 antibody; Nudix motif 3 antibody; Nudix type motif 3 antibody; NUDT 3 antibody; Nudt3 antibody; NUDT3_HUMAN antibody; P6-hexaphosphate hydrolase 1 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) NUDT3 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility.
Gene References into Functions
  1. Nudt3 is an mRNA decapping enzyme that orchestrates expression of a subset of mRNAs to modulate cell migration and further substantiates the existence of multiple decapping enzymes functioning in distinct cellular pathways in mammals PMID: 26932476
  2. results suggest that NUDT3 rs206936 is associated with body mass index in Japanese women PMID: 23708086
Subcellular Location
Cytoplasm.
Protein Families
Nudix hydrolase family, DIPP subfamily
Tissue Specificity
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
Database Links

HGNC: 8050

OMIM: 609228

KEGG: hsa:11165

STRING: 9606.ENSP00000351650

UniGene: Hs.188882

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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