nusB Antibody

Datasheet

Code	CSB-PA363966XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) nusB Polyclonal antibody

Uniprot No.

P0A780

Target Names

nusB

Alternative Names

nusB antibody; groNB antibody; ssyB antibody; b0416 antibody; JW0406 antibody; Transcription antitermination protein NusB antibody; Antitermination factor NusB antibody; N utilization substance protein B antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) nusB protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. The affinity of NusB for the boxA RNA sequence is significantly increased in the presence of the ribosomal protein S10. NusB may serve as a loading factor that ensures efficient entry of S10 into the transcription complexes. It also modulates the rrn boxA-mediated transcription elongation rates.

Gene References into Functions

Conservation of putative NusB/E binding sites upstream of Nus factor genes suggests that Nus factor autoregulation occurs in many bacterial species. PMID: 29229908
Authors propose that another major role for the Nus-modified transcription complex in rrn operons is as an RNA chaperone insuring co-ordination of 16S rRNA folding and RNase III processing that results in production of proper 30S ribosome subunits. PMID: 23190053
Strains carrying either a nusA mutation or a nusB mutation have defects in transcription of 23S rRNA. PMID: 15716433
NusB and NusE (S10) proteins binding to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli PMID: 16109710

Protein Families

NusB family

Database Links

KEGG: ecj:JW0406

STRING: 316385.ECDH10B_0372

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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nusB Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background