Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Oamb Polyclonal antibody

Uniprot No.

Q7JQF1

Target Names

Oamb

Alternative Names

Oamb antibody; oa1 antibody; CG3856 antibody; Octopamine receptor Oamb antibody; Octopamine receptor in mushroom bodies antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Oamb protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates. Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding. Required for ovulation. Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation. Ligand binding probably also leads to activation of CamKII which is also required for ovulation. Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness. Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females. Required in the mushroom body for appetitive olfactory learning. Specifically conveys the short-term reinforcing effects of sweet taste. In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3. Also plays a role in social behavior by modulating male agression.

Gene References into Functions

These results indicate that the OAMB receptor is a key molecule mediating the octopamine's signal for appetitive olfactory learning PMID: 23345239
Octopamine plays an important role in courtship conditioning through its OAMB receptor, expressed in a specific neuronal subset of mushroom bodies. PMID: 23055498
Results show that Ca2+ signaling initiated by octopamine receptor DmOctalpha1Rb (CG3856) is intimately controlled by kinase and phosphatase activities. PMID: 21478261
Data describe the requirement for the octopamine receptor OAMB in the body, but not in the brain, for female fecundity. PMID: 14623240
Expression of these unique octopamine receptors causes oscillatory increase of the intracellular Ca2+ concentration, activates adenylate cyclase, and induces a rise of intracellular cyclic AMP. PMID: 15816867
In neurons, exogenous mushroom body octopamine receptors activate the same signal pathway as endogenous mGluRs, suggesting that diverse neuronal responses mediated by Gq-coupled receptors are due to the properties of different neurons. PMID: 16289891
Our work provides the first evidence that adult abdominal type II visceral innervations co-express Glu and OA and allows us to re-evaluate the previous model of neuronal network controlling insect oviduct contraction. PMID: 16826564

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Highly enriched in mushroom body neuropil and in the ellipsoid body (at protein level). Expressed in oviduct epithelium (at protein level). Expressed in the adult and larval brain, thoracic and abdominal ganglia, terminal cells of the larval tracheal syst

Database Links

KEGG: dme:Dmel_CG3856

STRING: 7227.FBpp0303555

UniGene: Dm.3235

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Oamb Antibody

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Target Background