OPI1 Antibody

1. The work shows that transcriptional repressor Opi1p is redox-regulated and establishes a new mechanism of gene regulation involving Opi1p, which is important for adaptation to H2 O2 in yeast cells (Saccharomyces cerevisiae). PMID: 28581036
2. This study demonstrated that Pho85 binds to Opi1 in vitro and in vivo and that this interaction is increased in the presence of high concentrations of phosphate. PMID: 27743455
3. Opi1p dissociates from Scs2p after targeting to the nuclear membrane, making it possible to be released from the membrane quickly when phosphatidic acid levels decrease. PMID: 26590299
4. genes of phospholipid biosynthesis are negatively regulated by repressor protein Opi1 when precursor molecules inositol and choline are available. Opi1-triggered gene repression is mediated by recruitment of the Sin3 corepressor complex. PMID: 22543816
5. demonstrate that a physical association between the Yet complex and Scs2p-Opi1p is required for proper localization of the Opi1p repressor to endoplasmic reticulum membranes and subsequent INO1 derepression PMID: 21372176
6. a rapid decrease in intracellular pH in response to glucose starvation regulated binding of phosphatidic acid to Opi1, that coordinately repressed phospholipid metabolic genes; this enabled coupling of membrane biogenesis to nutrient availability PMID: 20798321
7. Two of the mutations in OPI1 (V343Q and S339F) provide genetic evidence for an interaction between Opi1p and the Ino2p activator since they reside in a region of Opi1p recently shown to interact with Ino2p in vitro. PMID: 16322993
8. casein kinase II phosphorylation at Ser10 plays a role in stimulating the repression of INO1 when Opi1p was not in its most active state PMID: 16407309
9. To better understand the mechanism of Opi1p repression, the viable yeast deletion set was screened to identify Opi(-) mutants. In total, 89 Opi(-) mutants were identified, of which 7 were previously known to have the Opi(-) phenotype. PMID: 16582425
10. This study revealed that a transcription factor that controls INO1 expression, called Opi1p, participates in the regulation of mat formation. Opi1p appears to modulate mat formation by influencing the expression of FLO11. PMID: 16896211

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KEGG: sce:YHL020C

STRING: 4932.YHL020C