ORCO Antibody

Code CSB-PA894717XA01DLU
Product Type Polyclonal Antibody
Uniprot No. Q9VNB5
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Drosophila melanogaster (Fruit fly) ORCO protein
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Odorant receptor coreceptor (Odorant receptor 83b) Orco A45 Or83b CG10609
Immunogen Species Drosophila melanogaster (Fruit fly)
Gene Names Orco
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Insect chemoreceptor superfamily, Heteromeric odorant receptor channel (TC 1.A.69) family, Orco subfamily
Tissue Specificity Expression is restricted to olfactory sensory neurons (OSNs). Coexpressed with Snmp in a lateral-distal population of OSNs. Expressed in the embryonic antennal-maxillary complex, in all 21 OSNs of the larval dorsal organ, in the pupal antennal OSNs, in al
Database Links

KEGG: dme:Dmel_CG10609

STRING: 7227.FBpp0112105

UniGene: Dm.25037

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