Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Orco Polyclonal antibody

Uniprot No.

Q9VNB5

Target Names

Orco

Alternative Names

Orco; A45; Or83b; CG10609; Odorant receptor coreceptor; Odorant receptor 83b

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Orco protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.

Gene References into Functions

Data suggest that Orco interactome, which includes physiologically meaningful candidates, would guide further research on the molecular mechanisms of the insect odorant receptor family. PMID: 29429152
OrcoS289 mutant flies unable to regulate Orco function through phosphorylation at S289 are defective for odor-guided behavior. PMID: 28871035
Both the defects are rescued by the somatic cyst cell-specific expression of the UAS-orco transgene. These results highlight a novel role of Orco in the somatic tissue during sperm release. PMID: 27240982
intracellular loop 3 is important for Orco channel activation PMID: 25271160
Study investigated the importance of two conserved Asp residues, one in each of transmembrane domains 5 and 7, for channel function by mutagenesis and found that the Asp residue associated with Orco TM7 is linked to channel activation. PMID: 23894621
The Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction. PMID: 15339651
DOR83b, an odorant receptor ubiquitously expressed in olfactory neurons from Drosophila melanogaster and highly conserved among insect species, forms heterodimeric complexes with other odorant-receptor proteins, increasing their function. PMID: 15592462
mutation of odorant receptor Or83b resulted in severe olfactory defects, altered adult metabolism, enhanced stress resistance, and extended life span PMID: 17272684
report a detailed topology mapping of the Drosophila OR83b receptor using engineered glycosylation sites as topology markers PMID: 18005664

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Insect chemoreceptor superfamily, Heteromeric odorant receptor channel (TC 1.A.69) family, Orco subfamily

Tissue Specificity

Expression is restricted to olfactory sensory neurons (OSNs). Coexpressed with Snmp in a lateral-distal population of OSNs. Expressed in the embryonic antennal-maxillary complex, in all 21 OSNs of the larval dorsal organ, in the pupal antennal OSNs, in al

Database Links

KEGG: dme:Dmel_CG10609

STRING: 7227.FBpp0112105

UniGene: Dm.25037

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Orco Antibody

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