ord Antibody

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Code	CSB-PA637592XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) ord Polyclonal antibody

Uniprot No.

Q24434

Target Names

ord

Alternative Names

ord antibody; CG3134 antibody; Protein ORD antibody; Orientation disrupter protein antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) ord protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Essential for proper maintenance of sister-chromatid cohesion in both male and female meiosis. Mutations in ord cause premature separation of the sister chromatids in meiosis I and random segregation in both meiotic divisions. Required for chiasma maintenance in female meiosis. Mutations in ord reduce recombination in female meiosis.

Gene References into Functions

Results suggest that association of orientation disruptor (ORD) with meiotic chromosomes during mid to late G2 is required to maintain sister-chromatid cohesion during prophase condensation. PMID: 12429833
Results suggest that orientation disruptor (ord) activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, promoting homologue bias during meiotic recombination in Drosophila. PMID: 15007062
If ORD activity is more severely disrupted, achiasmate chromosomes with the normal amount of pericentric heterochromatin exhibit increased nondisjunction when oocytes age. PMID: 19204374

Subcellular Location

Nucleus. Chromosome. Chromosome, centromere. Note=In male meiosis it assembles onto chromosomes in late G2 of the meiotic cell cycle. It remains at the centromeres after chromosome condensation, through the meiosis I division until the separation of sister chromatids at anaphase II.

Database Links

KEGG: dme:Dmel_CG3134

STRING: 7227.FBpp0071956

UniGene: Dm.3857

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ord Antibody

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