osa Antibody

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Code	CSB-PA808524XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) osa Polyclonal antibody

Uniprot No.

Q8IN94

Target Names

osa

Alternative Names

osa antibody; eld antibody; CG7467 antibody; Trithorax group protein osa antibody; Protein eyelid antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) osa protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation.

Gene References into Functions

Study shows that Osa induces a transcriptional program in the transit-amplifying population that initiates temporal patterning, limits self-renewal, and prevents dedifferentiation and identifies the Prdm protein Hamlet as a key component of this program. PMID: 24630726
Osa regulates intestinal stem cell self-renewal and differentiation into enterocytes by elaborating Notch signaling. PMID: 23942514
Osa belongs to Brahma chromatin remodeling complexes and negatively regulates ac/sc. PMID: 12629041

Subcellular Location

Nucleus.

Tissue Specificity

Ubiquitously expressed in early embryo. In third instar larvae, it is ubiquitously expressed in wing and eye-antenna imaginal disks, with a stronger expression in a band just anterior to the morphogenetic furrow.

Database Links

KEGG: dme:Dmel_CG7467

STRING: 7227.FBpp0088543

UniGene: Dm.2989

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osa Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background