otop1 Antibody

Datasheet

Code	CSB-PA773835XA01DIL
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: otop1 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa
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Product Details

Uniprot No.

Q7ZWK8

Target Names

otop1

Alternative Names

Otopetrin-1 otop1

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) otop1 protein (406-518aa)

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The otop1 polyclonal antibody is obtained through immunization of a rabbit with recombinant Danio rerio (Zebrafish) (Brachydanio rerio) otop1 protein (406-518aa), leading to the production of specific antibodies within the rabbit's IgG-rich serum. Subsequent purification via affinity chromatography yields a highly specific otop1 antibody, which demonstrates reactivity with Danio rerio (Zebrafish) (Brachydanio rerio) otop1 protein and is thoroughly validated for its performance in ELISA and WB applications.

The otop1 is a critical component in the formation of otoconia, which are specialized calcified structures in the inner ear that play a crucial role in balance and hearing. Mutations in the otop1 gene can lead to defective otoconia formation and, consequently, disruptions in balance and auditory function in zebrafish.

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Target Background

Function

Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol.

Gene References into Functions

Otopetrin 1 in zebrafish may be involved in the protein trafficking of components required for formation of biominerals in the ear. PMID: 15480759
Results demonstrate that otopetrin 1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith. PMID: 15581873

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Otopetrin family

Database Links

KEGG: dre:322893

UniGene: Dr.77257

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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otop1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background