ovo Antibody

1. Co-expressing ectopic SoxN with svb rescued diverse denticle morphologies. Conversely, removing SoxN activity eliminated the residual denticles found in svb mutant embryos. Furthermore, several known Svb target genes are also activated by SoxN, and we have discovered two novel target genes of SoxN that are expressed in denticle-producing cells and that are regulated independently of Svb. PMID: 28506986
2. Report the high-resolution functional dissection of a robust enhancer of the shavenbaby gene that has contributed to morphological evolution. We found that robustness is encoded by many binding sites for the transcriptional activator Arrowhead and that, during evolution, some of these activator sites were lost, weakening enhancer activity. PMID: 27840106
3. Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila. These low affinity sites conferred specificity for Ubx binding in vivo, but multiple clustered sites were required for robust expression when embryos developed in variable environments. PMID: 25557079
4. Multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo. PMID: 24218640
5. study shows peptides of 11 to 32 amino acids encoded by polished rice(pri)sORF gene control epidermal differentiation by modifying Shavenbaby (Svb); Pri peptides trigger amino-terminal truncation of Svb which converts Svb from a repressor to an activator PMID: 20647469
6. ovo-B is strongly expressed in the 2X germ cells in either a male or a female soma (ovo-B) PMID: 11861560
7. genetic and gene expression data show regulatory changes of the shavenbaby/ovo (svb/ovo) gene underlie independent cases of morphological convergence PMID: 12931187
8. shavenbaby governs an evolutionarily conserved developmental module consisting of a set of genes collectively responsible for trichome formation PMID: 16933974
9. SoxN is necessary and sufficient to cell-autonomously direct the expression of svb. PMID: 17611224
10. identification of three distinct svb enhancers from D. melanogaster driving reporter gene expression in partly overlapping patterns that together recapitulate endogenous svb expression. PMID: 17632547
11. Results show that the embryonic expression of dsc73 requires Shavenbaby, a transcription factor regulating cuticle formation. PMID: 18351665

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KEGG: dme:Dmel_CG6824

STRING: 7227.FBpp0291128

UniGene: Dm.1677