OXA1 Antibody

Code CSB-PA331102XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OXA1 Polyclonal antibody
Uniprot No.
Target Names
OXA1
Alternative Names
OXA1; PET1402; YER154W; Mitochondrial inner membrane protein OXA1; Cytochrome oxidase biogenesis protein OXA1; Oxidase assembly protein 1
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OXA1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane. Forms pores capable of accommodating translocating protein segments. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space.
Gene References into Functions
  1. observations suggest that the function of Oxa1 is relevant not only for the biogenesis of conserved mitochondrial components such as respiratory chain complexes or ABC transporters but also for mitochondria-specific membrane proteins of eukaryotic origin PMID: 22846909
  2. the close proximity of Oxa1 to ribosomes is not only used to improve membrane insertion but is also critical for the productive assembly of the subunits of the cytochrome c oxidase. PMID: 22904327
  3. Oxa1 behaves as a pore-forming translocase that is regulated in a membrane potential and substrate-dependent manner PMID: 22829595
  4. Findings show that the distribution of Oxa1 within the inner membrane is dynamic and adapts to different physiological needs. PMID: 22513091
  5. Deletion of OXA1 impairs the biogenesis of the three respiratory complexes of dual genetic origin. PMID: 15908145
  6. Oxa1 has the ability to accept preproteins within the membrane PMID: 16253275
  7. The phosphatidylethanolamine level of yeast mitochondris is affected by the mitochondrial components OXA1 and YME1. PMID: 17976194
  8. OXA1 complements a lack of yidC2 in S. mutans. PMID: 19366667

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
OXA1/ALB3/YidC family
Database Links

KEGG: sce:YER154W

STRING: 4932.YER154W

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