Accessory protein p30II Antibody

Code CSB-PA317235XA01HQG
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Alternative Names
Accessory protein p30II antibody
Raised in
Rabbit
Species Reactivity
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
Immunogen
Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) Accessory protein p30II protein
Immunogen Species
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
p30II is a multifunctional regulator that sequesters EP300/CREBBP and down-regulates CREB-responsive element (CRE) and Tax-responsive element (TRE) mediated transcription. Specifically binds and represses tax/rex mRNA nuclear export. Since Tax and Rex are positive regulators of viral gene expression, their inhibition by p30II reduces virion production, and allows the virus to escape the host immune surveillance and persist latently in an immune-competent host.; p13II increases mitochondrial permeability to monovalent cations, producing a rapid, membrane potential-dependent influx of potassium. This could involve a channel-forming activity. Interferes with cell proliferation and transformation and promotes apoptosis induced by ceramide and Fas ligand, probably using the Ras signaling.
Subcellular Location
[Isoform p30II]: Host nucleus, host nucleolus.; [Isoform p13II]: Host mitochondrion inner membrane.
Protein Families
HTLV-1 accessory protein p30II family
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1