Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Pabp2 Polyclonal antibody

Uniprot No.

Q7KNF2

Target Names

Pabp2

Alternative Names

Pabp2 antibody; rox2 antibody; CG2163 antibody; Polyadenylate-binding protein 2 antibody; PABP-2 antibody; Poly(A)-binding protein 2 antibody; dPABP2 antibody; Nuclear poly(A)-binding protein 1 antibody; Poly(A)-binding protein II antibody; PABII antibody; Polyadenylate-binding nuclear protein 1 antibody; Protein rox2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Pabp2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Plays a role in the positive regulation of alpha-1,3 fucosylation, possibly by cooperating with swm which regulates nuclear export of fucosyltransferase FucTA.

Gene References into Functions

the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1. We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy. PMID: 25816335
Results identify the poly(A) binding protein PABP2 as a regulator of maternal mRNA poly(A) tail length and highlight the importance of this mode of translational control. PMID: 16198293
Results suggest that oculopharyngeal muscular dystrophy does not result from polyalanine toxicity, but from an intrinsic PMID: 16642034

Subcellular Location

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Mostly found in the nucleus in the germarium. From egg chamber formation onwards, expressed in both the nuclei and cytoplasm of nurse cells and the oocyte. At stage 10, abundant in the nuclei of nurse cells, oocyte and follicle cells and in the cytoplasm of nurse cells. Uniformly distributed in the cytoplasm of early embryos then progressively localizes to nuclei during the pre-blastoderm and syncytial blastoderm stages. After cellularization, localizes mainly to the nucleus and remains nuclear in later embryonic and larval stages. During mitosis, expression levels are reduced in prophase nuclei and expression is localized to the cytoplasm during metaphase. Localizes to nuclear speckles.

Tissue Specificity

Expressed ubiquitously in all transcriptionally active cells.

Database Links

KEGG: dme:Dmel_CG2163

STRING: 7227.FBpp0087863

UniGene: Dm.521

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Pabp2 Antibody

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