PAF1 Antibody

1. results outline complex interactions, in cis and in trans, between genes encoding PAF1 and ESCRT-II complex components that affect telomere function and cell viability in yeast PMID: 29564528
2. work provides structural insights into the overall architecture of the Paf1 complex and paves the road forward for understanding the molecular mechanisms of the Paf1 complex in transcriptional regulation. PMID: 30224485
3. Our results are consistent with a model in which cotranscriptional methylation of histone H3 K4, mediated by the Paf1 complex and noncoding transcription, leads to activation of ECM3 transcription PMID: 27449519
4. Paf1 has 2 distinct functions: a core general function in transcription elongation, satisfied by the lowest Paf1 levels, and a regulatory function in determining differential transcript fate by varying the level of Paf1 on Pol2. PMID: 28190769
5. This study demonstrates that the recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex. PMID: 23775116
6. a broad requirement for the Paf1 in snoRNA 3'-end formation in S. cerevisiae PMID: 23109428
7. Ctr9 has function distinct from its established role in the Paf1 complex. PMID: 22446411
8. Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast. PMID: 22699496
9. By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter. PMID: 22252319
10. Paf1 and Ctr9 repress SER3 by maintaining SRG1 transcription-dependent nucleosome occupancy. PMID: 21873510
11. RNA polymerase II-associated factor 1 complex (Paf1c) has roles in different subpathways of nucleotide excision repair PMID: 21737840
12. Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment PMID: 20732871
13. Paf1C has an effect on newly synthesized mRNAs as they exit the nucleus PMID: 15643076
14. The PAF1 protein complex is associated with Pol II at initiation and during elongation, these critical Paf1-dependent changes in transcript abundance are due to alterations in posttranscriptional processing. PMID: 16246724
15. The Paf1 complex associates with and facilitates Nrd1 recruitment to the SNR47 gene, suggesting a direct involvement in 3' end formation. PMID: 16246725
16. Paf1 is required for silencing and lysine 4 (K4)-methylated histone H3 at the rDNA, suggesting a possible direct role for K4-methylated H3 in gene silencing. PMID: 16582434
17. Results indicate that Rtf1 influences transcription and chromatin structure through several independent functional domains and that Rtf1 may function independently of its association with other members of the Paf1 complex. PMID: 17576814
18. Paf1 complex genes, affect telomere length via telomerase RNA abundance PMID: 18411302
19. Paf1 complex provides a point of contact for recruitment of 3'-end processing factors at an early point in the transcription cycle. PMID: 18469135
20. Paf1C promotes Pol I transcription through the rDNA by increasing the net rate of elongation PMID: 19164765

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KEGG: sce:YBR279W

STRING: 4932.YBR279W