parn-1 Antibody

Code CSB-PA297956XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans parn-1 Polyclonal antibody
Uniprot No.
Target Names
parn-1
Alternative Names
parn-1 antibody; K10C8.1 antibody; 3'-5' exoribonuclease parn-1 antibody; Poly(A)-specific ribonuclease homolog 1 antibody; RNase parn-1 antibody; EC 3.1.13.- antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans parn-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in transcriptome surveillance. Required for piwi-interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.
Gene References into Functions
  1. Study shows that C. elegans deficient for PARN-1, a conserved RNase, accumulate untrimmed piRNAs with 3' extensions. Surprisingly, these longer piRNAs are stable and associate with the Piwi protein PRG-1 but fail to robustly recruit downstream silencing factors. PMID: 26919432
Subcellular Location
Cytoplasm.
Protein Families
CAF1 family
Tissue Specificity
Expressed in germline cells.
Database Links

KEGG: cel:CELE_K10C8.1

STRING: 6239.K10C8.1

UniGene: Cel.3035

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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