path Antibody

Code CSB-PA956098XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) path Polyclonal antibody
Uniprot No.
Target Names
path
Alternative Names
path antibody; CG3424Proton-coupled amino acid transporter-like protein pathetic antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) path protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors.
Gene References into Functions
  1. Path is a nutrient sensor with widespread function in Drosophila. PMID: 26735916
  2. mutation of pathetic impinges on nutrient responses and protein homeostasis specifically in neurons with large dendrite arbors but not in other cells. PMID: 26063572
Subcellular Location
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon. Cytoplasm.
Protein Families
Amino acid/polyamine transporter 2 family
Tissue Specificity
In third instar larvae, expressed at highest levels in the brain and digestive system with particularly high levels in surface glia of the brain (at protein level). In third instar larvae, expressed in all cells of the body wall (at protein level). Within
Database Links

KEGG: dme:Dmel_CG3424

STRING: 7227.FBpp0076156

UniGene: Dm.6315

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