pax2a Antibody

Code CSB-PA820864XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) pax2a Polyclonal antibody
Uniprot No.
Target Names
pax2a
Alternative Names
pax2a antibody; noi antibody; pax2.1 antibody; paxzf-b antibody; Paired box protein Pax-2a antibody; No isthmus protein antibody; Pax[Zf-b] antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) pax2a protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
Gene References into Functions
  1. Pax2a and Pax8 regulate cell differentiation during sensory placode formation PMID: 22745314
  2. Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development PMID: 22357656
  3. pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development PMID: 21215261
  4. wnt1 and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 at the midbrain-hindbrain boundary. PMID: 12591239
  5. hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. PMID: 14568547
  6. Pax2.1 is not only involved in initiating but also in maintaining the identity of midbrain and isthmus cells to prevent them from assuming a forebrain or hindbrain fate. PMID: 14579372
  7. Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation PMID: 15459102
  8. pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate PMID: 15604103
  9. Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. PMID: 18761336

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed during embryogenesis in the kidney, optic stalk, midbrain, otic vesicle and a row of cells along the spinal cord and the hindbrain.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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