PCH2 Antibody

1. pch2Delta showed approximately 50% genome-wide increase in crossover frequency, elevated noncrossovers and loss of chromosome size dependent double-strand break formation. PMID: 28315832
2. discuss our current understanding of the function of Pch2(TRIP13) during meiotic and mitotic cell divisions, with a focus on its enzymatic role towards HORMA domain-containing clients PMID: 25895724
3. Pch2 displaces Hop1 from large DNA substrates and both ATP binding and hydrolysis by Pch2 are required for Pch2-Hop1 transactions PMID: 24367111
4. Pch2 modulates chromatid partner choice during meiotic double-strand break repair in Saccharomyces cerevisiae. PMID: 21515575
5. tgs1Delta cells are specifically defective in splicing PCH2 meiotic pre-mRNAs. PMID: 21398639
6. PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PMID: 20711356
7. during WT meiosis, Pch2 promotes progression of SC-associated CO and NCO recombination complexes at a regulated early-midpachytene transition that is rate-limiting for later events PMID: 18305165
8. Roles of Pch2 in controlling both chromosome axis morphogenesis and crossover placement suggest linkage between these processes. PMID: 19629172
9. Study provides four evidence suggesting that PCH2 regulates the formation and distribution of crossover events required to promote chromosome segregation at Meiosis I. PMID: 19629178

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KEGG: sce:YBR186W

STRING: 4932.YBR186W