pcnB Antibody

1. Poly(A)polymerase I participates in the ability of the bacteria to adapt to and survive detrimental conditions by constantly monitoring and adjusting to its environment. PMID: 23123524
2. THe data demonstrates that regulation of PAP I is critical not for preventing the decay of mRNAs, but rather for maintaining normal levels of functional tRNAs and protein synthesis in E. coli, a function for polyadenylation that has not been observed previously in any organism. PMID: 23241393
3. Characterization of RNA fragments that accumulate in a PNPase deficient strain showed that Glu tRNA precursors still harbouring the 5' leader can be degraded by a 3' to 5' quality control pathway involving poly(A) polymerase. PMID: 22142150
4. Data show that the inactivation of Hfq leads to a reduction in the ability of poly(A) polymerase I to add poly(A) tails to mRNAs containing Rho-independent transcription terminators. PMID: 15522076
5. There are three transcription start sites upstream of the pcnB coding sequence; activities of at least two of these promoters are in inverse correlation to bacterial growth rates. PMID: 16330100
6. linker between transcription and mRNA degradation via sigmaS proteolysis with the ultimate goal of adapting and surviving to growth-limiting conditions. PMID: 16556229
7. Null mutations in pcnB, encoding poly(A) polymerase I (PAP I), and in hfq, encoding the RNA chaperone Hfq, suppress toxicity caused by overproduction of SprE. PMID: 19767441

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KEGG: ecj:JW5808

STRING: 316385.ECDH10B_0123