PCS1 Antibody

1. Findings suggest that the PCS1 protein (At5g44070) might be involved in the production of the enzyme phytochelatin synthase, which in turn bind, localize, store or sequester heavy metals in plant cells. PMID: 24554125
2. Recombinant AtPCS1s with mutations at Tyr55 showed lower catalytic activities because of reduced affinity (3-fold for Y55W) for the CdGS2, further suggesting the role of the cation-pi interaction in recognition of the second substrate. PMID: 24340051
3. Loss of AtNRAMP3 and AtNRAMP4 function or of PCS1 function leads to comparable Cd sensitivity. PMID: 22998565
4. Inducible expression of the Arabidopsis phytochelatin synthase AtPCS1 in the triple knockout yeast system, resulted in the turnover of glutathione-S-bimane to the gamma-GluCys-bimane conjugate as observed in plants. [phytochelatin synthase] [AtPCS1] PMID: 19897216
5. When AtPCS1 was overexpressed in Arabidopsis the A2::AtPCS1 plants were highly resistant to arsenic, accumulating 20-100 times more biomass on 250 and 300 microM arsenate than wild type. PMID: 15653797
6. Cd(2+) tolerance in cultured rolB roots was increased as a result of overexpression of AtPCS1, and further enhanced when reduced glutathione (GSH, the substrate of PCS1) was added to the culture medium. PMID: 16133212
7. Arabidopsis PCS1 in the cytosol importantly decreased cadmium tolerance, both cadmium tolerance and accumulation of plants expressing plastidial PCS1 were not significantly affected compared to wild-type. PMID: 16766112

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KEGG: ath:AT5G44070

STRING: 3702.AT5G44070.1

UniGene: At.7305