dnc Antibody

Datasheet

Code	CSB-PA893842XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) dnc Polyclonal antibody

Uniprot No.

Q9W4T4

Target Names

dnc

Alternative Names

dnc antibody; CG32498 antibody; cAMP-specific 3',5'-cyclic phosphodiesterase antibody; isoform I antibody; EC 3.1.4.53 antibody; Learning/memory process protein antibody; Protein dunce antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) dnc protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory.

Gene References into Functions

Hangover acts as a nuclear RNA binding protein and we identified the phosphodiesterase 4d ortholog dunce as a target RNA. PMID: 28076795
dunce knockdown in the mushroom body neurons impairs memory without significantly affecting acquisition. PMID: 25644700
Dunce phosphodiesterase plays a major role in the spatial regulation of cAMP dynamics. PMID: 20188656
These results indicate that calcium influx through acetylcholine receptors is increased in dunce and that calcium extrusion to the outside and/or calcium buffering are enhanced in dunce. PMID: 14660074
Choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways PMID: 17180701
flies responding to visual novelty revealed attention-like processes with stereotypical temporal properties; these processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga PMID: 17363675

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Protein Families

Cyclic nucleotide phosphodiesterase family, PDE4 subfamily

Database Links

STRING: 7227.FBpp0305507

UniGene: Dm.4817

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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dnc Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background