Pde4d Antibody

1. specific inhibitory PDE4D mutations can lead to the molecular pathology of acrodysostosis without hormone resistance but that the pathological phenotype may well be dependent on an over-compensatory induction of other PDE4 isoforms PMID: 25064455
2. PDE4D9 was found to locate primarily not only in the perinuclear region of Rat-1 cells but also at the cell margins. PMID: 24815749
3. Inhibition of PDE4D activity decreases hepatic inflammation, injury and fibrosis. PMID: 23887098
4. The effect of increased PDE4D expression following cerebral ischemia may play a role in changing blood-brain barrier permeability, which could secondarily affect ischemic outcome. PMID: 22860212
5. PHD2 may directly interact with PDE4D to function as a novel regulator of the intracellular cAMP levels in cardiomyocytes. PMID: 22975349
6. The rat model confirms Pde4d's role in depression but not in spatial learning or memory enhancement and shows for the first time higher fear conditioning and altered extinction compared with controls. PMID: 22487514
7. cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3 PMID: 20106966
8. Splenic tissue concentrations of alpha(2A)-AR, PDE4D, CD14, and TLR4 were significantly increased in septic aged rats as compared to aged sham rats and septic young rats. PMID: 20302880
9. The differential expression of PDE4D mRNA splice variants in the area postrema is consistent with their possible involvement in emesis control PMID: 12125047
10. Reported here the cloning and characterization of two novel PDE4D isoforms, PDE4D6 and PDE4D7. PMID: 12834813
11. Despite cyclic nucleotide increase at 30 min, the fundamental event causing memory impairment, came from the subsequent long time decrease of cAMP levels, due to the post-translational PDE4D induction. PMID: 15302115
12. The tissue distribution of multiple splice variants of PDE4D in various tissues of adult rats is reported. PMID: 15717866
13. To evaluate whether mRNA levels of Pde4d and Alox5ap were associated with hypertensive stroke and hypertension in stroke-prone renovascular hypertensive rats (RHRSP) which could simulate human being's hypertensive cerebral stroke. PMID: 17922411
14. Spectrin-anchored PDE4D4 shapes the physiological response to cAMP by directing it to barrier-enhancing effectors while limiting PKA-mediated microtubule reorganization. PMID: 18073242
15. Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes. PMID: 19060129

Show More

Hide All

KEGG: rno:24627

STRING: 10116.ENSRNOP00000067171

UniGene: Rn.160519