Pde6 Antibody

Code CSB-PA893747XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Pde6 Polyclonal antibody
Uniprot No.
Target Names
Pde6
Alternative Names
Pde6 antibody; CG8279 antibody; cGMP-specific 3',5'-cyclic phosphodiesterase antibody; EC 3.1.4.35 antibody; DmPDE5/6 antibody; DmPDE6 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Pde6 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells.
Gene References into Functions
  1. The first demonstration of a novel role for a cG-PDE in modulating cGMP transport and efflux in D. melanogaster Malphigian tubules is presented. PMID: 16232123
  2. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase-5/6 (DmPDE5/6) by prenylation and interaction with a prenyl-binding protein. PMID: 18503409
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Expressed on the apical side of the Malpighian tubule principal cell polarized membrane. Loss of prenylation causes protein location to the cytoplasm.
Protein Families
Cyclic nucleotide phosphodiesterase family
Tissue Specificity
Expressed in Malpighian tubule principal cells. Also expressed in adult head.
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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