Pdfr Antibody

1. Body temperature rhythm (BTR) is fundamental for the maintenance of functions essential for homeostasis, such as generating metabolic energy and sleep. One major unsolved question is how body temperature decreases dramatically during the night. Previously, we demonstrated that a BTR-like mechanism, referred to as temperature preference rhythm (TPR), exists in Drosophila Here, we demonstrate that the diuretic hormone 31 (D PMID: 27852781
2. Drosophila master pacemaker neurons perceive both PDF and glutamate via PDFR and mGluRA G-protein coupled receptors that increase or decrease intracellular cAMP, respectively in response to light stimulus. PMID: 25268747
3. our study identified the Pigment Dispersing Factor Receptor (PdfR) as a regulator of flight circuit development and as a modulator of acute flight PMID: 24098151
4. we show that PDF-R in pacemakers activates a different adenylate cyclase isoform PMID: 23929551
5. PDFR activation in LN(v)s shifts the balance of circadian activity from evening to morning, similar to behavioral responses to summer-like environmental conditions PMID: 22938867
6. PdfR is expressed by the muscles of the excretory system, and induces cAMP increases that underlie the myotropic effects of PDF. PMID: 22778427
7. PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila PMID: 21559487
8. Data suggest that small lateral PDF receptor-containing neurons directly target a subset of crucial pacemaker neurons, and that there is autocrine feedback signaling by PDF back to PDF-expressing cells. PMID: 20394051
9. The data of this study establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems. PMID: 16242402
10. groom-of-PDF is a G protein-coupled receptor required for neuropeptide Pigment-Dispersing Factor neuron action in circadian behavior. PMID: 16242403
11. Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons. PMID: 16242407
12. Using circuit-directed rescue of PDF receptor mutants, data show that PDF targeting of just approximately 30 non-PDF evening circadian neurons is sufficient to drive morning behavior. PMID: 19621061

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KEGG: dme:Dmel_CG13758

STRING: 7227.FBpp0300789

UniGene: Dm.17751