pdfr-1 Antibody

Code CSB-PA600242XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans pdfr-1 Polyclonal antibody
Uniprot No.
Target Names
pdfr-1
Alternative Names
pdfr-1; seb-1; C13B9.4; Calcitonin receptor-like protein 1; Pigment dispersing factor neuropeptide receptor homolog 1
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans pdfr-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity.
Gene References into Functions
  1. The PDFR-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. PMID: 23143519
  2. The pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant. PMID: 22579613
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family
Tissue Specificity
Expression was observed in the mechanosensory neuron pairs PLM, ALM, FLP, OLQD, and OLQV, the chemosensory neurons PHA, PHB, RMEV, the ring motor neurons RMED, and the pharyngeal interneuron pair I1. In both hermaphrodites and males at the L4 stage expres
Database Links

STRING: 6239.C13B9.4a.1

UniGene: Cel.22708

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